Genome-wide association study highlights strong genetic correlation between ASRD and depression

Genome-wide association study highlights strong genetic correlation between ASRD and depression

Nearly 40 million Americans experience anxiety every year. The entire process of determining the right treatment for anxiety is a stressful situation, including the experimentation with various medication to find the best treatment plan. For people suffering from mental illness, the decision to go for a particular treatment option is like a gamble involving a lot of trial and error.

This trial and error process becomes an unavoidable part of handling any psychiatric problem. Most of the treatment approaches involve antipsychotic medications that inflict a range of side effects, such as nausea, restlessness, dry mouth, suicidal thoughts, anxiety and agitation. However, one can avoid such side effects through increased awareness about the ingredients and other details of such medications like effectiveness in treating the problem, whether it will be metabolized or resisted by the body, etc.

Since anxiety and other stress-related disorders (ASRD) are polygenic in nature, one can effectively overcome the challenge of anxiety disorders by comprehending the variations in genes due to mental health issues. Genome-wide linkage data and genome-wide association studies have shown favorable genetic loci for anxiety disorders.

Determining common variants increasing susceptibility to ASRD and mental disorders

Considering that ASRD can create numerous expressions of abnormalities in the basic stress-response system, a new genome-wide association study tried to understand variations in the genes among 12,655 mice afflicted with anxiety and stress and 19,225 controls. The results showed alternations in PDE4B expression in the mice displaying anxious behavior due to chronic stress. Additionally, the study found that around 28 percent of the variance in ASRD was because of the common variants, with the genetic signature of ASRD overlapping with psychiatric traits, educational outcomes, obesity-related phenotypes, smoking and reproductive success.

Since most of the people going through ASRD tend to suffer from a comorbid psychiatric disorder, the above-mentioned study explored the impact on genetic expression by the comorbid disorders like ASRD and depression. Highlighting the importance of their study, they stated, “Our effort represents the first genetic study of this magnitude to explicitly target comorbidity of ASRD with other mental disorders.”

These investigations tried to seize the clinical complexity of anxiety and stress-related phenotypes in a sample developed for individuals with comorbid mental illnesses and known genetic variants that increase susceptibility to these diseases. One of the most consistent finding was that the genetic variants located within the PDE4B gene is primarily responsible for triggering anxiety.

The pharmacological profiles of selective PDE4B inhibitors exhibited clear antidepressant and anxiolytic benefits. Though more studies are needed to identify the genetics of different types of mental disorders, the aforementioned study certainly succeeds in highlighting the strong genetic correlation of ASRD and depression.

Don’t let anxiety go out of control

Each one of us struggle with some kind of anxiety or stress in our everyday lives. However, it can be managed by learning more self-control and developing effective coping strategies. Some people have the habit of worrying unnecessarily and excessively; hence, they find it hard to relax. It is particularly important for such people to seek professional support to recover from anxiety.

An untreated mental illness can go out of control and lead to other health complications. One of the most common and effective approaches in managing anxiety is cognitive behavioral therapy (CBT). Its primary principle is to alter the patient’s attitude toward life and bring behavioral changes gradually.

If you or your loved one is experiencing stress or anxiety, contact the Florida Helpline for Anxiety for help. Our representatives will be more than happy to find the state-of-the-art anxiety treatment center in Florida offering recovery programs in a compassionate environment. Call at our 24/7 helpline number 855-920-9834 or chat online with one of our representatives to access more details about the comprehensive and holistic anxiety disorders treatment in Florida.

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